1+ months

Associate Research Fellow, PKPD/QSP Modeling and Simulation

Pfizer
Cambridge, MA 02139
**ROLE SUMMARY**



This modeling and simulation leader will work within the Biomedicines Design preclinical translational modeling and simulation team. The successful candidate will be accountable for all preclinical modeling and simulation activities in support of Pfizer's large molecule oncology portfolio and may supervise a small group of more junior modelers. As a member of multidisciplinary project teams, the successful candidate will develop and implement quantitative mechanism-based PKPD and QSP models which impact the quality of decisions regarding target selection, target prioritization, therapeutic modality selection, protein optimisation, biomarker characterization and early clinical trial design. In addition, at a broader level, the successful candidate will be responsible for driving and advancing the translational modeling strategy for large molecules across the oncology research unit and would be involved in a number of enterprise level initiatives with other groups e.g. Clinical Pharmacology.



**ROLE RESPONSIBILITIES**



+ Oversee all PKPD and QSP modeling and simulation activities in support of the large molecule oncology portfolio.

+ Collaborate with multidisciplinary project teams to develop and implement mechanistic mathematical models of pharmacology (PKPD and QSP) to aid in target selection, target prioritization, therapeutic modality selection, protein optimisation, biomarker characterization and early clinical trial design.

+ Liaise with research biology/pharmacology/toxicology to help in the development of in-vitro assays and in-vivo models to generate data that inform pre-clinical to clinical translated PKPD models.

+ Provide expert support to project teams to design, execute and interpret quantitative pharmacology studies.

+ Collaborate and maintain an active relationship with Clinical Pharmacology and Pharmacometrics at the project level as well as in the advancement of modeling and simulations sciences.

+ Network as appropriate with global experts in the department and other groups to share learnings and enhance consistency in best practices across sites, disease areas, and therapeutic approaches.

+ Keep up to date with emerging literature and science in the QSP modeling and simulation sciences and immuno-oncology areas.

+ Continue to build a personal track record of publication in the area of PKPD modeling and simulation and contribute to the department's external publication/presentation goals consistent with our increased investments in the area of modeling and simulation.



**BASIC QUALIFICATIONS**



+ Ph.D. degree in mathematics, engineering or other disciplines related to quantitative pharmacology or equivalent experience with a strong emphasis on biopharmaceutical modeling and simulation.

+ 10 years of pharmaceutical industry based experience in developing and applying mechanism-based PKPD/QSP models to guide project teams from early discovery to early clinical development. Leader in the area of modeling and simulation.

+ Previous supervisory or leadership experience.

+ Excellent understanding of theory, principles and statistical aspects of advanced mathematical modeling and simulation.

+ Thorough understanding of the basic principles of pharmacokinetics (non-compartmental, compartmental, PBPK).

+ In depth, hands-on knowledge of the state of the art modeling and simulation software and applications in the area of PKPD modeling and simulation (Monolix, Matlab, Phoenix, Simbiology, R, NONMEM or comparable applications).

+ Experience working in the oncology disease area and with novel therapeutic modalities (e.g. bispecifics, cytokine-fusion proteins and other targeting agents).

+ Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop mechanistically-relevant PKPD/QSP models.

+ Ability to translate/condense/summarize outcomes of modeling and simulation analyses into information that can be used by project teams.

+ Ability to keep up-to-date with and propose the implementation of scientific and technological developments in the area of PKPD modeling and simulation.

+ Good team player and communicator.

+ Good listener and ability to effectively interact with colleagues with a variety of backgrounds.

+ Motivated to develop a career as a hands-on, technical modeling and simulation expert in a preclinical drug discovery environment.

+ Keen to interact as a modeling and simulation expert with matrix project teams working closely with departmental, Biology and Clinical scientists.

+ Strong belief that modeling and simulation can have a significant positive impact on research projects.

+ Committed to the development of self and others.

+ Motivated to share technical expertise with others.



**PREFERRED QUALIFICATIONS**



+ 3+ years of experience working in the oncology disease area and with novel therapeutic modalities (e.g. bispecifics, cytokine-fusion proteins and other targeting agents) is preferred.

+ 3+ years of supervisory experience is preferred.



**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.



**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.



\#LI-PFE



**Other Job Details:**



+ Eligible for Relocation Package

+ Eligible for Employee Referral Bonus



N (Other) (United States of America)

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

Categories

Posted: 2019-07-16 Expires: 2019-11-15

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Associate Research Fellow, PKPD/QSP Modeling and Simulation

Pfizer
Cambridge, MA 02139

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