23 days old

Pharmacology/Toxicology Sr. Principal Scientist

Pfizer
Boulder, CO 80302
Array BioPharma (recently acquired by Pfizer) is a biopharmaceutical company headquartered in Boulder, CO with locations in Cambridge, MA and Morrisville, NC. We are focused on the discovery, development and commercialization of targeted small molecule drugs to treat patients afflicted with cancer. Array recently received approval and launched BRAFTOVI (encorafenib) and MEKTOVI (binimetinib) for the treatment of patients with BRAF mutated melanoma. These products have also been granted Breakthrough Therapy Designation by the FDA for BRAF mutated CRC.



With more than 300 days a year of sunshine, Boulder is a paradise in the West! Hikers, bikers, foodies, beer enthusiasts, art and theater lovers, and more feel right at home here. Visit the https://www.bouldercoloradousa.com/ to discover what's we love about Boulder. Many Array colleagues live just outside of Boulder in Longmont, Westminster, Lafayette, and other surrounding communities and have commutes of only 15 to 20 minutes.



**Role Summary:**

This position is responsible for designing and performing complex pharmacology and toxicology studies. She/he will provide scientific guidance to project teams and across multiple partner lines in drug discovery and development. Ideal candidate will be able to act independently and collaboratively, with the potential to take on additional responsibility, including project team leadership and managing direct reports. Unique hands-on position with ability to contribute to the IND enabling process. Reports to the Vice President of Pharmacology and Toxicology.



**Responsibilities:**



+ Will conduct routine research in pharmacology and toxicology for use in Pfizer-Array projects.

+ Will conduct animal handling and restraint, compound dosing, inoculation and blood and tissue sampling.

+ Small animal surgical techniques, necropsy procedures, physiological monitoring, efficacy and pharmacodynamic assessments in various small animal models of human disease.

+ Design and monitor IND-enabling GLP toxicology studies and preparation of nonclinical regulatory submissions, integration of the data for the pharmacology and toxicology sections of the IND

+ Project team participation and opportunities for project team leadership



**Requirements:**



+ PhD with 7-10+ years / MS with 15+ years research experience in the pharmaceutical industry.

+ Extensive in vivo pharmacology and toxicology expertise required; specifically, for oncology-related drug development programs

+ Standard in vivo pharmacology testing skills are required

+ Experience in designing and performing a variety efficacy, pharmacodynamic and non-GLP toxicology studies, data collection, analysis and interpretation are required

+ Experience in designing and monitoring IND-enabling GLP toxicology studies and preparing nonclinical regulatory submissions is required

+ Candidates should possess excellent communication skills and the ability to multi-task in a fast-paced environment

+ Demonstrated ability to work independently

+ Ability to communicate effectively, both written and oral



**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.



**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.



**Other Job Details:**



+ Eligible for Relocation Package

+ \#LI-PFE



Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.



Research and Development

Categories

Posted: 2019-11-18 Expires: 2019-12-18

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Pharmacology/Toxicology Sr. Principal Scientist

Pfizer
Boulder, CO 80302

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