1+ months

Postdoctoral Research FellowImmunotherapeutic Design

Pfizer
La Jolla, CA 92037
ROLE SUMMARY



The Cancer Immunology Discovery (CID) group in La Jolla, CA, generates large molecule immunotherapeutics that promote anti-tumor activity or counter immunosuppression in the tumor microenvironment.

Together with the Oncology Medicinal Chemistry group that focuses on the structure elucidation of protein small molecule complexes with anti-tumor efficacy, we are seeking a qualified candidate to join us as a Postdoctoral Fellow.

The successful candidate will work across both groups to elucidate the structural basis of unconventional peptide presentation by MHC I molecules and the effect on activation of CD8+ T cells and NK cells.

The candidate will design HLA allele-specific peptides, characterize their interaction with MHC class I using protein crystallography, and assess their activity in vitro assays.



**ROLE RESPONSIBILITIES**



+ Expression of MHC I alleles and refolding with designed peptides using established refolding methods

+ Structure determination of MHCI-peptide complexes using X-ray crystallography

+ Measuring NK cell activation using cytotoxicity assays

+ Staining of CD8+ T cells and NK cells using flow cytometry

+ Dissemination of results via peer-reviewed publications and presentations



**BASIC QUALIFICATIONS**



+ Recent PhD in Immunology, Biochemistry, or related discipline with first author publication(s) in peer-reviewed and internationally renowned journals

+ Technical expertise in protein expression and purification, as well as protein crystallography.

+ Cell-culture, cytotoxicity assays (e.g DELFIA immunoassay)

+ The ability to plan and execute experiments independently



**PREFERRED QUALIFICATIONS**



+ Flow cytometry experience

+ Protein-protein/ Protein-cell interactions (SPR, BLI, FCM)

+ Strong understanding of molecular biology and protein biochemistry.

+ Motivated, proactive, and eager to learn.

+ Excellent communication and presentation skills.

+ Advanced molecular design proficiency.



Eligible for Employee Referral Bonus



Eligible for Relocation Package Benefit



\#LI-PFE



**Sunshine Act**

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**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.



Research and Development

Categories

Posted: 2020-04-16 Expires: 2020-05-30

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Postdoctoral Research FellowImmunotherapeutic Design

Pfizer
La Jolla, CA 92037

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