1+ months

Principal Scientist, BioMedicine Design, Protein Engineering

San Francisco, CA 94102

BioMedicine Design's Antibody Engineering Group, based at Pfizer's Center for Therapeutic Innovation (CTI) San Francisco, is seeking a Principal Scientist to discover and engineer therapeutic proteins. The candidate will be an essential member of the Biomedicine Design - The Centers for Therapeutic Innovation (CTI) - California Protein Engineering Group and will have a demonstrated record of leading drug discovery programs. He/she will use molecular biology expertise, phage/yeast display, protein expression, purification and biological characterization in the development of protein therapeutics .


The candidate will be responsible for all aspects of protein therapeutic discovery and optimization including antibody selection, screening, characterization, removal of liabilities, humanization and affinity maturation.


+ A PhD Degree in Molecular Biology, Biochemistry, or related life science discipline

+ 5+ years post PhD experience in laboratory research, preferably in an industry setting

+ Strong molecular biology skills including DNA subcloning, cDNA library building, DNA mutagenesis design and PCR techniques

+ Experience in assay development, including protein-protein binding assays, ELISA and Western blot

+ Working experience with phage and/or yeast antibody display libraries is required

+ Experience designing panning and screening strategies that will enable the selection of desirable antibodies/peptides against targets

+ Excellent written and oral communication skills

+ It is essential for the individual to work with other group members as a team

+ Strong publication record


+ Next Generation Sequencing experience is a plus

+ Experience in protein expression, purification and characterization is a plus.


+ Ability to perform mathematical calculations and ability to perform complex data analysis


**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

**Other Job Details:**

+ Eligible for Relocation Package: yes

+ Eligible for Employee Referral Bonus: yes

N (Other) (United States of America)

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.


Posted: 2019-08-16 Expires: 2020-01-12

Before you go...

Our free job seeker tools include alerts for new jobs, saving your favorites, optimized job matching, and more! Just enter your email below.

Share this job:

Principal Scientist, BioMedicine Design, Protein Engineering

San Francisco, CA 94102

Join us to start saving your Favorite Jobs!

Sign In Create Account
Powered ByCareerCast