1+ months

Principal Scientist Cell

La Jolla, CA 92037

**Pfizer's Cancer Vaccine & Immunotherapeutics (CVIT) group in La Jolla, CA is developing state-of-the-art cancer vaccine and oncolytic virus-based immunotherapy regimens that will benefit cancer patients.**

**We are seeking a Principal Scientist Cell-Based/Virology Assay Lead to join the Molecular & Cellular Biology team in CVIT.** The successful applicant will use their extensive knowledge and hands on experience of cell biology, virology (BSL2/BSL2+ viruses), and associated cell-based assays to support cancer vaccine discovery and development projects. They will have a passion for research, a track record of success in this area, excellent communication skills and strong management experience. Previous industry experience with a solid foundation in vaccine or drug discovery would be an advantage.

**This is a laboratory based role with supervisory responsibilities.** Areas of responsibility will include the co-ordination and execution of established cell-based virology assays, and the maintenance/ supply of multiple cell lines to end-users (96-well plate to Cell-factory scale). Additional scientific and technical contributions to exploratory novel assay development will also be expected. The successful candidate will be able to independently and proactively apply their knowledge in the design, execution, trouble-shooting, analysis and interpretation of experimental work. They will also identify opportunities/ technologies for quality and efficiency improvements in the team. Additionally, as a member of project teams, they will be accountable for the delivery and critical appraisal of their results (and those of others), presenting them for review at meetings and specific project milestones.

**Significant knowledge and hands-on technical experience in two or more of the following areas is essential:** culture of diverse mammalian cell lines, including normal cells and/or primary cell isolation and maintenance; generation and selection of clonal recombinant cell lines; cell-based assays for virus characterization (e.g. TCID50, plaque, virus replication, virus neutralization, cell viability); use of reporter cell lines and/or viruses; development and characterization of robust cell-based assays relevant to virology, oncology or immunology; monitoring of assay performance; statistical analysis and graphical representation of complex data sets.

**Direct supervisory experience of scientists working in the above area(s) is highly desirable.**

**Additional experience in one or more of the following areas is preferred:** cell-based assay automation; quantitative protein expression analysis (e.g. Western Blot, ELISA); development and/or execution of molecular assays (e.g. qPCR/qRT-PCR).


**Laboratory and related work (60-80% of time) under minimal supervision:**

+ Experimental design, execution, analysis & critical interpretation of results

+ Will have and maintain technical skills and experience in virology and cell-based assays as well as ensuring they are fully conversant with the operation and validation of all items of equipment or IT needed for experimentation, data analysis, storage, and data entry.


+ Will directly supervise a team of scientists, with indirect/matrix supervision of additional scientists, directing daily research activities.

+ Will be responsible for practicing real time performance management, conducting annual performance appraisals, and

developing robust career development plans for direct reports.


+ Will comply with all EH&S regulations and safe laboratory practices and identify/ act to reduce hazards and risks in the laboratory.


+ Ph.D in biological sciences, cell biology, or virology with 4+ years relevant laboratory experience, preferably in an industrial setting

+ M.S. in biological sciences, cell biology, or virology with 9+ years relevant laboratory experience, preferably in an industrial setting.

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.


**Other Job Details:**

+ Additional Location Information: La Jolla, CA

+ Eligible for Relocation Package

+ Eligible for Employee Referral Bonus

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.


Posted: 2019-07-10 Expires: 2019-11-13

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Principal Scientist Cell

La Jolla, CA 92037

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