9 days old

Principal Scientist, Enzymology DMPK

Pfizer
Groton, CT 06340
**Role Summary**



Pfizer is seeking a dynamic and collaborative experimental scientist for a Principal Scientist position contributing to ADME (absorption, disposition, metabolism and excretion) sciences in the in vitro enzymology and preclinical pharmacokinetics (PK) group.



The individual will be joining a dynamic group in ADME Sciences Enzymology, Department of Medicine Design, in support of the global Pfizer small molecule discovery research and development portfolio. The qualified candidate will be responsible for design, conduct and advancing in vitro enzymology, oversight of nonclinical pharmacokinetic studies, and/or modeling and simulation studies in support of ADME principles for programs. The individual will be a member of matrix teams comprised of other ADME discipline scientists and led by a project representative, with expectations that integrated information resolves ADME issues and advances programs. The role includes supervision and mentorship of laboratory staff, responsibility for experimental conduct or oversight, and resource management relevant to our therapeutic areas. The individual will also be expected to advance scientific understanding, grow effective partnerships externally as well as internally to incorporate growing technological advances, and incorporate novel experimental approaches to address challenging dispositional issues.



**Responsibilities**



+ Provide scientific leadership and enzymology knowledge or expertise for lab-based portfolio support and scientific innovation relevant to ADME sciences.Relevant areas include understanding of drug clearance, tissue binding and disposition, reaction phenotyping, enzyme kinetics, enzyme inhibition/induction or relevant DDI data generation, and delivery or conduct of quality preliminary or definitive ADME studies in support of regulatory filings.

+ Working with modeling and simulation scientists, take scientific leadership for the predictions of clearance (IVIVE) and drug-drug interactions.This includes directing or undertaking physiologically based PK (PBPK) modeling strategies, which support and achieve project goals or address regulatory interactions.

+ Advise discovery and development project teams regarding approaches to understand and optimize dispositional attributes and to address any regulatory filings for clinical candidates.

+ Continue to build Pfizer's strong external network in PK and enzymology sciences to integrate advances at academic centers (eg tissue co-culture, MPS, tissue impairment) with our internal strategy and capabilities, and where appropriate, to progress precompetitive topics via collaborations and consortia.

+ Guide and develop laboratory-based scientists focused on the design and conduct of novel low- and medium-throughput in vitro assays to support discovery and definitive development assays for regulatory filings.

+ Review and approve DMPK study protocols, research reports, nonclinical ADME summaries, and abstracts/manuscripts for publication.

+ Direct original research aligned with the research priorities established by the Medicine Design Strategic Imperatives and Business Plan, as well as ongoing assay conduct to support the Pfizer discovery and development portfolio.

+ Proactively establish and grow effective partnerships externally as well as internally across multiple disciplines (e.g. Clinical Pharmacology, Pharmaceutical Sciences, Medicinal Chemistry, Computational Sciences, High Throughput Screening) to advance scientific innovation in the realm of ADME and to develop synergistic packages of scientific capabilities to support the portfolio.



**Basic Qualifications**



+ PhD or equivalent with 2+ years of relevant postdoctoral academic or industry experience in the scientific field.Candidates with a diverse scientific background (eg pharmaceutical sciences, drug metabolism, pharmacokinetics, biochemistry, chemistry, biology, biomedical sciences, or engineering) are encouraged to apply.

+ A keen interest in growing knowledge and optimizing dispositional attributes of small molecules through ADME enzymology science and technology is required.

+ Experience working in matrix teams within and across technical/research line organizations, a collaborative problem solver.

+ Training in people and organizational leadership skills and supervisory skills.

+ Strong leadership and interpersonal skills as well as a track record of enthusiasm to deliver results in a fast-paced environment.

+ Highly effective written, presentation and verbal communication skills are essential.



**Preferred Qualifications**



+ In-depth knowledge and experience in relevant areas of small molecule enzymology science and technology (eg phenotyping, competitive and/or time-dependent enzyme inhibition, induction, protein binding, tissue distribution, microsomal, hepatocyte and tissue fraction studies, or tissue culture).

+ ADME project representation or small molecule discovery and development experience.

+ Experience in pharmacokinetic data analysis (e.g. noncompartmental analysis), understanding of therapeutic exposure-effect relationships, and hands-on experience with physiologically-based (PBPK) modeling using tools such as Watson, Phoenix WinNonlin, Berkeley Madonna, MATLAB, and/or Simcyp is desirable.

+ Recognition for creativity and innovation through strong publication/presentation record.

+ Experience in advanced cell culture techniques such as co-culture or tissue engineering (eg MPS) experience is highly desirable.

+ Proficiency in the use of Microsoft Office Suite of tools (Outlook, Word, Excel, etc.) and hands-on experience establishing IVIVE, computational ADME predictions, and data visualization tools.



**Physical/Mental Requirements**



+ Conduct of experiments will require the scientist to work in the laboratory, including standing, walking, sitting, and lifting solvents.



**Non-Standard Work Schedule, Travel or Environment Requirements**



+ Periodic travel will be required to other Pfizer sites (eg Cambridge, MA; La Jolla, CA) or to attend and present at scientific conferences.



\#LI-PFE



**Other Job Details:**



+ Eligible for Relocation Package

+ Eligible for Employee Referral Bonus



**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.



**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.



Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.



Research and Development

Categories

Posted: 2019-11-08 Expires: 2019-12-14

Before you go...

Our free job seeker tools include alerts for new jobs, saving your favorites, optimized job matching, and more! Just enter your email below.

Share this job:

Principal Scientist, Enzymology DMPK

Pfizer
Groton, CT 06340

Join us to start saving your Favorite Jobs!

Sign In Create Account
Powered ByCareerCast