1+ months

Principal Scientist (PhD), Biophysics

La Jolla, CA 92037

Pfizer Oncology R&D in La Jolla, California is seeking an accomplished Principal Scientist in Biophysics to join the Biochemistry and Quantitative Pharmacology group. The successful candidate will evaluate kinetics and thermodynamics of drug-protein interactions and protein dynamics. The successful candidate will operate with a high level of independence in providing biophysical data and insight as a part of multi-disciplined scientific research teams. The successful candidate will directly contribute to advance our cancer drug discovery portfolio at a technical and strategic level.


The successful candidate for this position will:

Work independently as a discipline expert to characterize small molecule-protein interactions using label-free biophysical methods (SPR, ITC, thermal stability-based assays, MST, native MS)

Regularly represent the biophysics group on multi-disciplinary teams to provide scientific insights into kinetics and thermodynamics of protein-ligand interactions

Display growing knowledge and understanding of other disciplines relevant to early stage drug discovery

Mentor and train colleagues in biophysical methods

Identify and integrate emerging biophysical technologies to strengthen current capabilities within the group


PhD degree in Biophysics, Biochemistry or closely related field with 3-5 years of drug discovery experience in a pharmaceutical industrial or academic laboratory setting.

Demonstrated expertise in the use of label-free biophysical methods (SPR, ITC, MST, Native MS and thermal stability assays such as DSF) for characterization of protein-ligand interactions

Hands on experience in high-throughput screening and plate-based pharmacology

Experience in handing a diverse range of recombinant proteins as tools in biochemical or biophysical assays

Share our core values of courage, excellence, equity, and joy that form the basis of our collaborative scientific culture

Outstanding publication record reflecting scientific drive and creativity across multiple disciplines

Excellent oral and written communication skills, excellent interpersonal skills to facilitate knowledge sharing and scientific discussions, a team player


Experience in fragment or small-molecule screening using biophysical methods

Experience in cellular thermal stability assays (CETSA) for target engagement is desirable but not required

Knowledge and understanding in the area of enzymology, mechanisms of drug action and structural biology

Relevant experience in the area of difficult-to-drug targets would be valued


Interacts with scientists from multiple scientific and technical disciplines within Pfizer (biochemistry, structural biology and protein sciences, tumor biology, chemistry) at the La Jolla site as well as other Pfizer locations. May interact with scientist from contract research organizations on a need basis.


**Other Job Details:**

+ Eligible for Relocation Package

+ Eligible for Employee Referral Bonus

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


Posted: 2020-09-29 Expires: 2020-12-02

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Principal Scientist (PhD), Biophysics

La Jolla, CA 92037

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