1+ months

Principal Scientist Virus Production

Pfizer
La Jolla, CA 92037
**ROLE SUMMARY**

Pfizer Vaccine Research and Development (VRD) seeks to discover novel vaccines (prophylactic and therapeutic) for the prevention and treatment of significant human diseases (e.g. infectious diseases, oncology) using a variety of vaccine technology platforms combined with immunomodulatory agents.



We are seeking a Principal Virus Purification scientist to join the Early Bioprocess Development Group (EBPD), La Jolla, California, to lead the development, process transfer and support of virus purification processes from pre-clinical research scale to Ph1 production scale.



The successful candidate will have expert knowledge and extensive experience in virus purification. In addition the individual will have sound knowledge and training in chemical/biochemical engineering principles related to separation and purification of biologicals - preferentially live virus purification- with a proven record of leading downstream purification process development, scale-up and process transfer in an industrial setting to supply both Regulatory Toxicology and clinical trial material. The successful candidate will be required to work with Cat-2 infectious agents.



The individual will be skilled in the process development, optimization and scale-up of the following:



+ Virus purification using chromatographic techniques

+ Cell lysis, harvest and clarification techniques

+ Tangential flow filtration - Both ultra and microfiltration

+ Enzymatic digestion steps

+ Dead-end filtration

+ Ultracentrifugation based purification - both batch and continuous flow.



Additional desirable skills would include:



+ Virus production at bioreactor scale

+ Virus/protein characterization techniques

+ Vaccine development

+ Statistical experimental design - DOE

+ Experience in safe handling of Cat-2 infectious viruses - i.e Adenovirus & Vaccinia



The individual will be required to work independently, to supervise and direct the research of other colleagues in their reporting line and matrix supervise colleagues as project needs dictate. As a member of project teams they will be accountable for the critical appraisal of their groups work and results and present them for review, at specific project milestones.

The role is supervisory and laboratory based, and a major emphasis is placed upon laboratory training and supervision of other colleagues to increase the group scope of practical abilities, as well as the theory behind such practical work. The individual's specialist knowledge and skills will be transferred to members of the group by working alongside colleagues in the laboratory so as to ensure scientists are developed for future leadership succession.

The individual will have responsibility for establishing reproducible protocols for virus purification that fall within agreed product specifications and are accompanied by reports that could be used for IP filings, documentation required to underpin regulatory documents and or/Investigator Brochure supportive data packs and or IP filings. The individual will have responsibility for technology transfer of virus purification protocols within Pfizer or to external CMOs as required.

As group lead the individual will be responsible for coordinating their resources with other discipline heads and Research Project Leads within VRD La Jolla and as necessary with colleagues from Biotherapeutics Pharm Sci and EBPD groups to ensure delivery of project goals.



**ROLE RESPONSIBILITIES**



EXPERIMENTAL/LABORATORY & RELATED WORK (50-60%):



+ Will oversee experimental design of scientists in the virus purification group

+ Will review scientist's analysis and critical interpretation of experimental data, results and methodology used.

+ Will work with virus purification scientists to plan and execute a series of experimental tasks to address specific scientific objectives of the project.

+ Will work alongside virus purification scientists in the lab as necessary to transfer knowledge and skills for working with state-of-the-art purification techniques.

+ Will be an accomplished scientist with notable track record of success and problem solving in all aspects of virus purification

+ Will regularly use the scientific literature and electronic information critically to enhance understanding of disease/technology area and generate novel methods and testable hypotheses to support ongoing or start new projects



MANAGEMENT



+ Will supervise colleagues in the Early Bioprocess Development group with additional matrix and contingent worker supervision as appropriate to project workload.

+ Will direct daily research activities of colleagues in group in all aspects of virus purification to support VRD projects in the discovery of novel vaccines

+ Will be responsible for liaising with colleagues in EBPD and Biotherapeutics PharmSci for knowledge and process transfer prior to Reg.Tox. & CTM manufacture.

+ Will liaise with EBPD group leadership and project teams to establish priorities of research deliverables

+ Will be responsible for constructing goals, practice real time performance management, and conduct annual performance appraisals for colleagues in the group.

+ Will develop robust career development plans for colleagues and actively engage colleagues in career development opportunities as they arise



DOCUMENTATION



+ Ensure that group generates SOPs, study reports and protocols in appropriate time frames

+ Ensure that EBPD group writes up electronic laboratory notebooks regularly in compliance with Pfizer IP policy.

+ Preparation of materials for internal and external presentations capturing groups plans/achievements



COMMUNICATION



+ Will have effective communication skills, both verbal and written; listens and understands well.

+ Regular 1:1 and group communication with supervisor and team colleagues and other colleagues within the VRD.

+ Regularly present at internal meetings/poster sessions and present and publish in the broader scientific community.

+ Will regularly contribute and influence at the discipline, project team and program team level in a leadership or team member capacity.



Safe working and regulatory compliance



+ Work safely themselves and be aware of EHS practices of other colleagues.

+ Completion of risk assessments, compliance training as required

+ Acts independently to maintain a safe and EHS compliant desk and workspace



**BASIC QUALIFICATIONS**



+ BSc in in biological sciences or Biochemical/chemical engineering with 12 years relevant laboratory experience

+ MSc in biological sciences or Biochemical/chemical engineering with 9 years relevant laboratory experience

+ PhD in biological sciences or Biochemical/chemical engineering with 4 years relevant laboratory experience



\#LI-PFE



**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.



**Other Job Details:**



+ Eligible for Employee Referral Bonus



Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

Categories

Posted: 2019-10-17 Expires: 2020-01-18

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Principal Scientist Virus Production

Pfizer
La Jolla, CA 92037

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