1+ months

Scientist, Protein Biology & Crystallization

Boulder, CO 80302
A career at Pfizer offers opportunity, ownership and impact. All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have opportunities to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

**Research Unit overview**

Pfizer- Boulder Research and Development, located in Boulder, Colorado USA, is a fully integrated drug discovery unit focusing on research and development of targeted small molecule therapeutic agents to treat patients afflicted with cancer.


We are seeking a protein crystallization specialist to join the Structural Biology group at Pfizer- Boulder Research and Development Unit. This individual will work closely with our protein crystallographer to express, purify, and crystallize a variety of challenging proteins for use in both structural and mechanistic studies.


+ Perform E. coli growth and recombinant protein expressions at liter-scale

+ Establish purification protocol and purify recombinant proteins from source cells

+ Design and conduct protein crystallization trials, crystal optimization, and X-ray data collection

+ Document experimental data

+ Communicate research priority, progress, and results with project teams

+ Contribute to written and oral presentations related to research findings

+ Provides technical and scientific guidance to junior research associates within the team

**Basic Qualifications**

+ Minimum Bachelor of Science degree with 6+ years' post-graduate, or Master of Science degree with minimum 5+ years' post-graduate, research experience in protein purification and crystallization.

+ Experience in recombinant protein expressions in E. coli

+ Independent bench-scientist capable of purifying proteins at multi-mg scale; familiar with AKTA purifier system and standard analytical techniques associated with assessing protein purification process

+ An expert in producing high-resolution, diffracting protein crystals, and able to collect data set for crystallographers

+ Strong organizational, problem-solving, and written/oral communication skills

**Preferred Qualifications**

+ Familiar with crystal handling and data collection at synchrotron facilities

+ Experience in or familiar with biochemical or biophysical assays on protein functions

**Physical/Mental Requirements**

+ Able to lift 50lb objects with dimensions 12 inches in height and 26 inches in width

+ Able to visualize microscopic objects under microscopes

**Non-Standard Work Schedule, Environment Requirements**

+ Able to adhere to safe work practices and perform lab works with appropriate personal protection equipment such as but not limited to safety goggles, facial mask, gloves, lab coat/ protective gowning, and closed toe shoes

+ Able to work at flexible hours occasionally when performing time-sensitive experiments

**Other Job Details**

+ Eligible for Employee Referral Bonus

+ \#LI-PFE

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


Posted: 2020-08-10 Expires: 2020-09-25

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Scientist, Protein Biology & Crystallization

Boulder, CO 80302

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