18 days old

Scientist, Upstream Process Development

Pfizer
Andover, MA 01810
**ROLE SUMMARY**

A Scientist (R3) position is available in the Upstream Process Development group within the Bioprocess R&D organization. The successful applicant will join a team of scientists and engineers focused on developing and optimizing mammalian cell culture processes for production of recombinant proteins and biologics for early- and late-phase human clinical trials. In this role, the candidate will be responsible for designing and execute mammalian cell bioreactor experiments in bench-top bioreactors and associated scale-down equipment with the goal of developing robust, scalable, and high productivity processes that produce therapeutic proteins with appropriate product quality attributes to treat human diseases. The work will also involve working with pilot scale, commercial and clinical production facilities to ensure accurate technology transfer, successful large-scale production and associated regulatory filing activities. The candidate may also be involved in cutting edge technology development projects that seek to improve production processes both from a process engineering as well as a biological perspective that have the potential to intensify mammalian cell culture processes.



**ROLE RESPONSIBILITIES**



+ Responsible for execution of bioreactor and shake flasks experiments in an effort to develop manufacturing processes for mammalian cell lines producing therapeutic biological molecules of interest.

+ Responsible for leading up-stream process scale-up efforts in support of the Pfizer biologics portfolio including execution of lab and pilot scale bioreactor experiments.

+ Participates and significantly contributes to discussions in lab and project team meetings on design of experiments (bioreactor and shake flask) and interpretation of experimental data.

+ Acts as a technical resource within the upstream group. Provides formal/informal mentoring to junior colleagues within work group/project team.

+ Works under limited supervision with periodic review of achievement of results and experimental approaches employed. Manages own time to meet agreed targets. Develops plans for short-term work activities on own projects.



+ Contributes to safe, efficient, effective and harmonious lab environment, ensures appropriate cleanliness and status/ operability of shared or assigned lab space or equipment; strong lab citizen and collaborative team player; approaches the job with energy and commitment; frequently demonstrates initiative.

+ Ensures effective, high-quality, timely and appropriate documentation in electronic laboratory notebooks and internal technical reports; presents data/ strategy to scientists and management in appropriate internal and external venues (technical meetings, project team meetings, conferences) as appropriate.



**BASIC QUALIFICATIONS**



+ Bachelor's degree with 7+ years' industrial experience OR Master's degree with 3-5 years' industrial experience in the area of Chemical/Biochemical engineering, Cell Biology, Biochemistry, Biotechnology, Microbiology, or related fields

+ Significant experience with process scale up to pilot and commercial GMP manufacturing

+ Strong mammalian cell culture expertise required, knowledge pertaining to other heterologous expression systems desirable

+ Significant experience working with small-scale bioreactors (1-3 Liters) within an industrial setting

+ An in-depth knowledge of bioreactor operations and in particular fed-batch and/or perfusion modes of cell culture

+ Strong trouble-shooting skills and extreme attention to detail required

+ Excellent oral and written communications skills



**PREFERRED QUALIFICATIONS**



+ Prior experience in developing commercially relevant cell culture processes to produce pharmacologically active proteins

+ Experience working with miniature bioreactors (ambr15) in a bioprocessing setting

+ Knowledge of cell line development and regulatory submissions

+ Knowledge of various aspects of cell physiology including metabolism and glycosylation

+ Visibility in mammalian cell culture community as a technical expert with growing scientific contributions in form of external presentations or publications



**Other Job Details:**



+ Last Date to Apply for Job: September 22, 2020

+ Eligible for Employee Referral Bonus

+ \#LI-PFE



**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.



**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.



Research and Development

Categories

Posted: 2020-08-31 Expires: 2020-10-14

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Scientist, Upstream Process Development

Pfizer
Andover, MA 01810

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