1+ months

Senior Associate Scientist, Immunopharmacology

La Jolla, CA 92037

Cancer Vaccines and Immunotherapeutics seeks to discover novel vaccines for the prevention and treatment of various cancers by using a variety of vaccine technology platforms in combination with immunomodulatory agents. We are searching for a motivated individual with practical experience in the implementation of fit for purpose murine tumor models and a scientific understanding of tumor biology and tumor immunology. The candidate will be required to proactively apply their knowledge and experience to execute in vivo experimental work plans provided by their supervisor and effectively conduct their work semi-independently and as a member of the ImmunoPharmacology team. The candidate will be required to summarize and critique their results, with guidance from their supervisor, as well as on occasion communicate data effectively at work-group meetings. This role is laboratory based with a major emphasis placed upon executing murine tumor models. The primary role is to assist in the execution of murine tumor models that are designed to understand/refine the mechanism of action responsible for the preclinical efficacy of cancer vaccines and similar immunotherapeutic approaches.


**Tumor Biology Research**

With direction, assist other team members in conducting murine tumor models that measure the preclinical efficacy of cancer vaccines and similar immunotherapeutic approaches.

**Primary Responsibilities** - Vivarium/Laboratory and related work (~90 of time) with supervision:

Assist in the design and execution of studies of in vivo immuno-oncology-related models in a vivarium

Perform routine animals handling, multi route dosing, tumor measurements, bleeding and terminal procedures.

Collect and process tissues and blood for ex vivo analysis.

Identify and report any experimental problems, troubleshoot causative factors, and suggest necessary corrections in discussion with supervisor.

Support general laboratory operations including ordering and re-stocking laboratory supplies, maintaining a clean and safe work environment and maintenance of equipment.

Regularly records experimental work upon completion in electronic notebook systems and archives instrument raw data on server databases.

**Scientific/ Technical Knowledge**

Demonstrated experience in murine tumor models with a basic scientific understanding of tumor biology and tumor immunology.

Common laboratory practices such as making solutions and buffers, dilution and other calculations, etc


Communicates effectively with ImmunoPharmacology team members.

Actively contributes ideas in group and line meetings.

Provides clear, concise and timely responses for data and experimental information to line manager.


+ One or more AALAS certifications (ALAT, LAT, or LATG)

+ HS diploma or equivalent required

+ 3+ years of experience working in a laboratory setting performing in vivo murine experiments

+ Practical understanding and application of statistical methods to experimental design and outcome measures

+ Good oral and written communication skills

+ Effective in communication skills both verbal and written; listens and understands well. Excellent interactive skills with people with diverse backgrounds and perspectives

+ Proactively recognizes needs and problems, and independently identifies and implements effective steps and solutions


+ B.S. degree in life sciences (no AALAS certification necessary). Will also consider candidates who have 2 years of college level credits

+ Experience with murine tumor models including tumor volume measurements and multi route dosing

+ Preference for local candidates (no relocation assistance)


Standing, sitting, bending, lifting, walking in a laboratory or vivarium setting.

Use of Personal Protective Equipment (PPE) in a BSL-2 laboratory; additional PPE requirements when working in vivarium barrier suites.

Standard business office conditions; sitting, standing as appropriate


Lifting, sitting, standing, walking, bending, repetitive pipetting, ability to perform mathematical calculations, ability to read, understand, and perform written protocols, and ability to perform moderately complex data analysis using Microsoft Excel, GraphPad Prism or other similar data analysis software.

Routine off-hour and weekend schedule


+ Adherence to La Jolla EHS policies and training; ability to work with human, non-human primate or murine blood samples and organ tissues.

+ Will be required to work with BSL2 infectious viruses (e.g. Vaccinia virus, adenovirus, and influenza) and must receive and maintain required vaccinations or provide satisfactory proof of same.

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.


**Other Job Details:**

+ Additional Location Information: La Jolla, CA

+ Eligible for Employee Referral Bonus

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

Research and Development


Posted: 2019-08-19 Expires: 2020-01-08

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Senior Associate Scientist, Immunopharmacology

La Jolla, CA 92037

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