1+ months

Senior Associate Scientist, Ligand Binding

Andover, MA 01810

Work under supervision of Senior Scientist or higher providing bioanalytical support for large molecules. Assist with the development of robust and reliable ligand binding and cell-based assays suitable for characterizing the disposition (PK) and Immunogenicity of biotherapeutics in various matrixes using a range of potential platforms and assay techniques. Deliver drug concentration and immunogenicity data to BMD principal investigators. Assist with development and validation of assays to be governed per departmental SOP. Engage in accurate execution and documentation of bioanalytical methods in a regulatory compliant manner. Ensure GLP/GCP compliance is maintained in laboratory during study support. Provide Bioanalysis for Biotherapeutic compounds, under the guidance of a bioanalytical principal investigator. This includes the development and implementation of ligand binding assays (e.g. ELISA, ECL detection, Gyros) to measure compound concentration, detection the presence of anti-drug antibody and neutralizing anti-product antibody activity in a regulated environment; The design, development and implementation of appropriate cell-based assays; Data analysis and interpretation and drawing conclusions regarding progress and results of work; Gathering input from BMD colleagues, other departments, literature, and additional resources to assist in driving the project forward.


+ This is a complete laboratory-based position 5 days a week.

+ Design, develop and implement ligand binding assays (e.g. ELISA, ECL detection, Gyros) in biological matrix (plasma, serum) to measure compound concentration, detect the presence of anti-drug antibody and neutralizing anti-product antibody activity in a regulated (GLP, GCP) environment.

+ Perform data analysis and interpretation and be able to draw conclusions regarding progress and results of work, utilizing the data in appropriate decision making.

+ Gathers input from colleagues, literature, and additional resources to assist in driving the project forward. Knowledge and hands-on experience developing ligand binding assays, utilizing various platforms.


+ Bachelors degree with at least 2 years of industry experience, research experience, or a related occupation, OR Master's degree/foreign degree equivalent in Chemistry, Biology or related field with 0 years of experience. *** medical and diagnostic technicians, as well as academic lab (NIH) experience will be considered.

+ Hands on Ligand Binding Assay (LBA) experience

+ Experience with Meso Scale Discovery (MSD) ECL platform

+ Adaptability to changing work assignments and priorities

+ Collaborative skills and effective partnering skills in a complex, multi-discipline organizational model

+ Excellent teamwork, Interpersonal and communication skills, strong attention to detail


+ Experience with cell-based bioassays

+ Automation experience

+ Skill set supporting molecular biology testing

+ Gyros

+ Experience in a regulated environment is desirable.


Other Job Details

+ Last Day to Apply for Job: March 11th 2021

+ Eligible for employee referral bonus

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development



Posted: 2021-03-17 Expires: 2021-05-19

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Senior Associate Scientist, Ligand Binding

Andover, MA 01810

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