1+ months

Senior Principal Scientist, Enzymologist

La Jolla, CA 92037

The Pfizer Oncology Research & Development group in La Jolla is seeking a full-time Enzymologist/Biochemist to support the drug discovery process to create innovative cancer therapies. The successful candidate will provide expert scientific and technical expertise towards the discovery and pre-clinical development of innovative small molecule drugs for cancer cell cycle targets, including cyclin-dependent kinases. The successful candidate will work with a high degree of independence to provide biochemical insight on enzyme targets as well as impact drug discovery project teams at a high strategic level.


- Provide strategic, intellectual, and technical leadership for the molecular and kinetic characterization of cancer cell cycle targets (e.g. enzymes) and the development of effective lead discovery assay-cascades that advance innovative drugs through our preclinical pipeline

- Lead/ contribute to the establishment of methods to characterize and understand the pharmacology of cancer cell-cycle drug candidates; specifically, characterization of mechanism of action and efficacy of targeted kinase inhibitors for multiple preclinical oncology projects

- Lead/ contribute to the establishment of programs to identify relevant biomarkers for cancer cell cycle drug candidates

- Demonstrate strong leadership, personal accountability and interpersonal skills, and capability for mentoring junior colleagues (direct reports and others), and establish safe, high-quality lab practices

- Ensure high-quality, timely documentation in electronic laboratory notebooks and Technical Reports, and contribute to Regulatory Filings and responses to Regulatory questions as appropriate

- Present data/ strategy to scientists and management in internal and external venues (technical meetings, Project Team meetings, conferences) and publish in peer-reviewed journals, as appropriate

- Maintain current in relevant literature and innovative technologies and their application to drug discovery, particularly in areas of tumor and normal cell cycle biology and targeted kinase inhibitors


-The candidate must have a Ph.D. in biochemistry or cell biology (or related field) with 8+ years of experience in small molecule drug discovery with a strong track record of success as evidenced by increasing responsibility and publication record.

-The individual will be a recognized scientific and technical expert with cell cycle proteins, including cyclin-dependent kinases and cyclins and highly experienced in methods to identify and characterize kinase inhibitors and their biochemical and cellular function/activities, including kinetic methods to character the mechanism of inhibition of small molecule kinase ligands.

-A well-established ability to develop robust, functional in vitro assays for the discovery of small molecule kinase inhibitors is required.

-Corresponding or senior-authored publications in top-tier journals is also a prerequisite.

-The candidate must demonstrate strong leadership, personal accountability and interpersonal skills, and capability for mentoring junior colleagues (direct reports and others), and establish safe, high-quality lab practices.

-In addition, the candidate should display a strong strategic understanding of small molecule drug discovery within a biotech or biopharma environment and have a broad understanding of cross-discipline drug discovery processes within a project team.

-A scientific background in oncology and/or cell cycle biology and drug discovery is strongly preferred.

-The candidate should possess excellent communication skills (written, verbal), proven leadership skills, and the demonstrated ability to make good decisions and influence teams to advance projects and navigate the complexities of cancer cell cycle drug discovery.

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.


Relocation eligible

Eligible for employee referral bonus


N (Other) (United States of America)

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.


Posted: 2019-06-26 Expires: 2019-10-09

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Senior Principal Scientist, Enzymologist

La Jolla, CA 92037

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