27 days old

Senior Principal Scientist

Pfizer
Groton, CT 06340
**Why Patients Need You**



Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.



**What You Will Achieve**



In your role, you will be joining a team of pharmacokinetics, dynamics & metabolism (PDM) scientists primarily supporting products in later stage development. Your position will be responsible for synthesizing the PDM knowledge, optimizing the PDM development strategy, and executing that strategy. Your position will also partner with other PDM scientific leaders to advance the ADME science and strategies for prosecuting primarily small molecule projects and may also influence external scientific and regulatory practices through publication and other interactions.



As a Senior Principal Scientist, you will be at the center of our operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be recognized as an outstanding scientist in your group. With your advanced knowledge of the discipline, you will regularly contribute in multi-disciplinary teams representing the department and influencing cross-functional teams. Your innovation is seen in way you promote the use of novel experimental approaches, create processes ,hypotheses and methodologies. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience. You will be entrusted with identifying and developing scientific strategies to support scientific goals and set the direction for business unit projects. You will undertake mentoring activities to guide team members.



It is your hard work and leadership that will make Pfizer ready to achieve new milestones and help patients across the globe.



**How You Will Achieve It**



+ Provide scientific leadership and strategic direction to assigned projects from idea to Proof-of-Concept and through to Registration and Post-Market.

+ Act as a scientific resource within own sub-function/therapeutic area/discipline.

+ Work with bioanalytical and ADME scientists to ensure the appropriate experimental plans.

+ Interface with biomarker scientists, PK/PD modelers, and Research and Business Unit partners to develop the translational pharmacology plan, PK and dose predictions for small molecule therapeutics.

+ Interface with partners in Clinical Pharmacology and Drug Safety to integrate nonclinical pharmacokinetic (PK), pharmacodynamic (PD) and metabolism knowledge, and influence the project plans in order to optimize drug development.

+ Advance the science and strategies for prosecuting projects as well as influence external scientific and regulatory practices through publication and other interactions.

+ Keep abreast of scientific/ technological developments by participating in scientific meetings/seminars and through regular scientific review.

+ Ensure adequacy, timeliness, and high quality of studies to meet scientific and regulatory requirements of the U.S. FDA, and Drug Regulatory Agencies worldwide.

+ Present experimental results at group meetings, project meetings and department meetings.

+ Provide guidance to team members and customers regarding operating unit and research functions.

+ Mentor/lead/manage other pharmacokinetics and drug metabolism team members.



**Qualifications**



**Must-Have**



+ PhD level education with 8 or more years experience (or MS/BS with equivalent experience) in relevant field

+ Excellent oral, written and presentation skills.

+ Excellent interpersonal relationship skills.

+ Mechanistic modeling of pharmacokinetics (PK).

+ Broad understanding ADME and in vitro drug metabolizing enzyme and transporter assays.

+ Understanding of bioanalytical sciences generally by LC-MS/MS.

+ General understanding of PK/PD modeling and its application to advance projects.

+ Ability to integrate data from multiple sources in to a rational understanding of drug disposition.

+ Proficiency in human PK and DDI predictions.

+ General understanding of drug discovery, chemistry and pharmacology.



**Nice-to-Have**



+ Experience in the preparation of regulatory applications (IND, NDA) and knowledge of regulatory guidelines is highly desirable.

+ General knowledge of biotransformation and physical organic chemistry.

+ SimCYP experience preferred.

+ Collaborative skills and effective partnering skills in a complex, multi-discipline organizational model.

+ Proven track record in the area of mentoring and coaching.



Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.



**NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS**



This position is global in nature and involves working with colleagues at various Pfizer sites and as such working times may be beyond core business hours. Working beyond core business hours can typically be done remotely, e.g., working from home. Approximately 2 or 3 times a year travel to other Pfizer sites for collaborative work.



**Additional Job Information:**



+ Locations: Groton, CT, Cambridge, MA, La Jolla, CA

+ Relocation Support Available

+ Eligible for employee referral bonus

+ Hybrid Onsite/Remote Schedule



\#LI-PFE



**Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.**



**Sunshine Act**



Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.



**EEO & Employment Eligibility**



Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.



Research and Development

Categories

Posted: 2022-04-18 Expires: 2022-05-18

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Senior Principal Scientist

Pfizer
Groton, CT 06340

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