1+ months

Senior Principal Scientist, Medicinal Chemistry and Molecular Design

Pfizer
Cambridge, MA 02139
**Would you like to discover the medicines of the future?**

At Pfizer we deliver Breakthroughs That Change Patients Lives . In the Medicine Design group we play a vital role in this mission through the discovery of Pfizer's small molecule and synthetically-derived drugs. We are seeking leaders in Medicinal Chemistry to join our world-class Medicine Design team in Cambridge MA to build upon our rich history of innovation in Medicinal Chemistry and Molecular Design and deliver Pfizer's drugs of the future.



Discovering new medicines at Pfizer takes teams with a diversity of skills, behaviors and approaches. Creativity, scientific excellence, tenacity, passion, hard work, organization, teamwork, courage, open-mindedness, curiosity - are just some of the traits successful Drug Discovers display at Pfizer, and we are looking for ambitious Medicinal Chemists, eager to see their work lead to important new medicines and scientific breakthroughs, to join our team.



The Medicine Design group in Pfizer comprises experts in the major scientific disciplines involved in the discovery and preclinical development of small molecule drugs: molecular design, synthesis, computational chemistry, pharmacology, chemical biology, structural biology, biophysics, DMPK and analytical chemistry. We have long been renowned not only for delivering high quality drug candidates into the clinic but also for establishing new drug design approaches and principles, such as the "Rule of 5" and property-based drug design, that have raised the bar of quality in the discipline and been widely-adopted across the industry.



As a Senior Principal Scientist in Medicinal Chemistry and Molecular Design at Pfizer you will play a vital role as leader or key contributor of a large, multi-disciplinary matrix teams from project inception through to delivery of clinical drug candidates. You will also lead or provide key contributions to teams of scientists looking to combine Pfizer's expertise and large-scale research investments, with external academic and biotech collaborations, to revolutionize our approach to the discovery and development of small molecule and synthetically-derived drugs.



**Role Responsibilities**



+ Accountable for driving a strong scientific agenda and the application of expert data analysis and contemporary design tools to drive effective target design and prioritization within a portfolio of projects

+ Contribute to medicinal chemistry strategy and devising hit ID strategies to move projects through the Hit-to-Lead phase with scientific excellence, efficiency and speed

+ Partner with enabling functions within Medicine Design to lead projects through the Lead Optimization phase, ensuring the delivery of small molecule/synthetic drug candidates with scientific excellence, efficiency and speed

+ Contribute to the identification of new small molecule projects to the portfolio through collaborations with disease area biologists

+ Influence innovation and excellence in Medicinal Chemistry through advocating novel approaches, methods and modalities to the drug discovery process

+ Play a key role in enhancing the external reputation of Pfizer's Medicinal Chemistry, Molecular Design and synthetic Drug Discovery capabilities through high profile publications and presentations at leading conferences

+ Work with local leadership to put in place an active program of self-development in medicinal chemistry and molecular design skills



**Qualifications**

**Basic Qualifications**



+ Doctorate level degree in relevant area of science, or equivalent industrial experience

+ Minimum 5 years of relevant experience in the Pharmaceutical Industry

+ Track record of delivering high impact contributions to Med Chem projects

+ Expert working knowledge of the key Medicinal Chemistry concepts and design tools required for pharmaceutical drug discovery

+ Consistent record of peer-reviewed publications from scientific work to date, to include medicinal chemistry/ drug discovery



**Preferred Qualifications**



+ Examples of high impact publications in Medicinal Chemistry/ Drug Discovery

+ Experience of playing a leading role in matrixed teams of internal/CRO scientists to deliver project objectives

+ Demonstrated learning agility and success moving into and mastering new or unfamiliar areas of science.



**Along with a Resume/CV, please include a short research summary of your relevant research.**



**Other Job Details:**



+ Eligible for Relocation Package

+ Eligible for Employee Referral Bonus

+ \#LI-PFE



**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.



**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.



Research and Development

Categories

Posted: 2020-09-14 Expires: 2020-11-13

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Senior Principal Scientist, Medicinal Chemistry and Molecular Design

Pfizer
Cambridge, MA 02139

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