1+ months

Senior Scientist, Biophysics

La Jolla, CA 92037

Pfizer Worldwide Research and Development La Jolla, has an open position for a talented and high-performing biophysical research scientist in the Structural Biology and Protein Sciences (SBPS) Group within the Department of Oncology Medicinal Chemistry. Candidates who have demonstrated an ability to perform innovative and high-quality research, working both independently, and as part of teams are encouraged to apply.


The candidate will contribute to a core biophysics SBPS team, collaborating with colleagues across the SBPS group as a resource in multi-disciplinary drug discovery team settings, contributing to robust and timely problem solving and decision-making. The successful candidate will demonstrate significant expertise applying in-depth biophysical characterization of protein targets intended for X-ray crystallography, cryo-EM and biochemical assays to support SBDD platforms and impacting projects at a strategic level.


PhD and postdoctoral experience in Protein Biophysics, Biochemistry or a closely related field.

Extensive biophysics background, with demonstrated expertise in biophysical characterization of proteins and macromolecular complexes (fluorescence spectroscopy, SEC-MALS, DLS/SLS, Mass Photometry, SAXS).

Expertise in analysis (data acquisition and interpretation) of protein interactions (small molecule, protein and nucleic acid) (ITC, SPR, MST, FP), and associated thermodynamic and kinetics parameters.

Ability to develop and integrate impactful and cutting-edge protein biophysical methods to strengthen and further build on current capabilities within SBPS.

Responsible to train colleagues, ensure operation of existing biophysics instrumentation, and help drive the identification and utilization of emerging technologies to strengthen and build on current capabilities within SBPS.

Excellent oral and written communication skills

Excellent interpersonal skills which facilitate knowledge sharing and scientific discussions

Outstanding publication record reflecting scientific drive and creativity across multiple disciplines of modern structural biology and protein sciences

Ability to quickly and effectively operate, communicate and influence decision making within cross-functional and multi-disciplinary drug discovery teams


Understanding of NMR, mass spectrometry and biochemical analysis/enzyme assays would be beneficial.

Experience with weak affinity ligands (fragments) and covalent inhibitors.


**Other Job Details:**

+ Eligible for Employee Referral Bonus

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


Posted: 2020-07-23 Expires: 2020-10-23

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Senior Scientist, Biophysics

La Jolla, CA 92037

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