14 days old

Senior Scientist, Protein Engineering

La Jolla, CA 92037

BioMedicine Design (BMD) is seeking a highly motivated and innovative scientist to join a protein engineering group supporting the Biotherapeutics portfolio of Pfizer, Inc. in La Jolla, CA. Responsibilities will be driving therapeutic innovation through technology development and contributing to the pipeline, including designing and hands-on execution of molecular biology, protein expression, protein purification, and protein engineering tasks. In-depth understanding of protein structure-function relationship and cutting-edge protein engineering techniques will be key to this position. The ideal candidate will be highly proficient in the design of protein/antibody constructs, protein expression and purification, and has good understanding of biology.


Integral member of a highly-collaborative team executing on time-sensitive protein engineering projects all the way from antibody/antigen design & generation through protein purification and characterization.

Independently evaluate and trouble-shoot experiments in a timely manner.

Participate in developing creative approaches to discover and optimize antibody-based biologics, evaluate novel modalities

Desire to understand underlying biology and mechanism of targets and biologics and ability to run biological assays.

Present results regularly at team meetings and drive data-driven decisions

Perform diligent and timely note-keeping and work process tracking


PhD in molecular biology/biochemistry/structural biology or a related discipline is required with at least 2+ years of post-doctoral training.

Extensive experience engineering proteins with desired properties

Technically proficient in protein engineering tools, including construct design, molecular biology (restriction cloning, Gibson assembly), protein expression in E.coli and mammalian/insect cell systems, protein purification (affinity chromatography, SEC, ion exchange, gravity or chromatography mode) and characterization (SDS-PAGE, endotoxin, binding, in vitro activity).

Experience with data analysis and presentation software

Excellent written and oral communication skills

An innovator with track record in molecular design of biologics, of creative and proactive approach to problem solving, and strong analytical skills.

Strong track record of scientific accomplishments demonstrated through publications in highly regarded journals and/or intellectual property generation.

Strong motivation, passion and commitment to science and engineering of novel entities

Ability and desire to work in an interdisciplinary scientific team and the desire to learn new techniques

The ability to work closely with other group members within teams is essential


Experience with antibody and biotherapeutic discovery and a working knowledge of antibody molecules

R&D experience in an industry setting with good understanding of biologics drug development is preferred

Training in immunology and cell biology is highly desirable. Previous experience with antibody engineering

Experience with high throughput screening methods

Experience with protein display methods

Experience with protein-small molecule conjugation is a plus

Experience with LC/MS characterization of protein samples, especially for antibodies and other biotherapeutics would be desirable

Familiar with protein modeling tools such as Rosetta


Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis tasks.


**Other Job Details:**

+ Eligible for Employee Referral Bonus

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


Posted: 2020-10-13 Expires: 2020-11-12

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Senior Scientist, Protein Engineering

La Jolla, CA 92037

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